Incretins by JackTsuchiyama

If anyone has diabetes or is worried about their blood sugar and loves to eat rice, it sounds like you should eat meat first to keep your blood sugar stable. In the article they specifically mention fish and beef.

I looked into what incretin is, as the article specifically mentioned the chemical. Turns out that incretins are gut hormones “that are secreted from enteroendocrine cells into the blood within minutes after eating.” These hormones are what regulate the amount of insulin released.

There are 2 types of incretins: Glucose-dependent insulinotropic peptide (GIP) and Glucagon-like peptide-1 (GLP-1). These have a common action in the pancreas but differentiate their function once outside the pancreas. They are enzymatically degraded rapidly by dipeptidyl peptidase 4 (DPP4).

Typically, Type 2 diabetes targets GLP-1 receptors since GIP is incompetent for beta-cell function as it no longer modulates glucose-dependent insulin secretion. Basically, GIP is made useless in the physiological conditions of Type 2 diabetes, though I’m not too sure why.

So it sounds like, from the article, eating meat prior to rice increases the incretin production so that there’ll be insulin to degrade the rice when you eat it.

Kim, Wook; Egan, Josephine. “The Role of Incretins in Glucose Homeostasis and Diabetes Treatment” (12 Dec 2008). Available


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